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The International QSAR Foundation hosts strategic planning workshops to bring together experts for the development of implementation plans for alternative approaches to animal testing. IQF devotes a minimum of 50 percent of its research resources to targeted grants to experts in order to turn the research implementation plans into alternative methods and reduced reliance on testing.

2nd McKim Workshop on Reducing Data Redundancy in Cancer Assessment

Baltimore

The objectives of this workshop series are (1) to review QSAR screening methods for grouping chemicals based on their potential to induce carcinogenesis through genotoxic and epigenetic pathways, and (2) to evaluate the combined use of structural domains and in vitro data to reduce the need for the rodent carcinogen assay. The 1st McKim Workshop focused on genotoxic carcinogens, and on the potential for the cell transformation assay to identify epigenetic carcinogens. This 2nd workshop will further explore key events in epigenetic pathways as well as discuss the structural attributes for chemicals that impact those pathways.

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Last Updated (Wednesday, 08 August 2012 19:01)

 

McKim Workshop on Data Redundancy in Cancer Assessment, Duluth MN May 19-21, 2010

duluth

The McKim Conferences on Predictive Toxicology will host a special workshop on opportunities for streamlining the array of toxicity tests used in assessments of carcinogenicity.  Evaluating short-term in vitro and in vivo data often assumes that alternative test methods have global chemical domains, and the resulting ambiguities tend to propel testing toward the expensive, long-term rodent carcinogen assay.  This retreat will consider a hypothesis-testing framework for organizing short-term evidence of low-incident in vivo risks and more efficient cancer assessments. Participation will be by invitation only, but registration for a limited number of observers will begin in March.

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Last Updated (Saturday, 13 February 2010 11:42)

 

Workshop on Modeling Reactive Toxicity, Logan UT March 23-25, 2010

Utah STate University Campus

3rd Workshop on Reactive Toxicity University Inn and Conference Center Utah State University March 23-24, 2010

Predicting the hazards of reactive chemicals is a major uncertainty in safety assessment because of inadequate models for chemical reactivity, itself. Two IQF retreats in Knoxville explored the role of reactive toxicity in predictive toxicology and published a conceptual framework for improving QSAR models for chemical reactivity. That framework outlined a series of systematic databases for model compounds which mimic reactive sites in biological systems. T.W Schultz et al. created the first of the databases for glutathione reactivity, and the data are used to predict a variety of assessment endpoints such as skin and lung sensitization, aquatic toxicity and cellular assays. The Logan retreat by invitation only will review progress and discuss options for the next database.

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Last Updated (Saturday, 13 February 2010 12:03)

 

The McKim Conference on Predictive Toxicology, Duluth, MN, September 16-18, 2008

duluth_aThe 2008 McKim Conference provided illustrations of why QSAR models for complex effects endpoints required a knowledge of toxicity pathways in order to simulate the adverse effects of chemicals in animal tests. The 2008 McKim Conference also provided the basic structure of a visualization system for toxicity pathways which describes the biological effects linkages across different levels of biological organization. The International QSAR Foundation has created Effectopedia as a web-based tool to assist in the acquisition of biological response mechanisms and the associated biological knowledge bases which must be associated with these mechanisms to describe the most likely toxicity pathway. The next McKim Conference will be a "traveling" conference to demonstrate the use of Effectopedia with QSAR models and solicit expert volunteers to participate in compiling a biological database that is useful in modeling adverse effects across species and levels of biological observation. For more information on Effectopedia, please watch this website for announcements of the McKim Conference venues.

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Last Updated (Sunday, 14 February 2010 07:52)

 

The McKim Conference on Predictive Toxicology, Duluth, MN, September 25-27, 2007

The 2007 McKim Conference reviewed the paradigm shift that is needed to improve the efficiency of hazard assessment and the role of chemical categories in beginning a transition to the hypothesis-driven paradigm. Further, the conference examined the IQF conceptual framework for predictive toxicology and the new QSAR models for estrogen receptor binding. Finally, the conference discussed the integration of QSAR and system biology as an approach for identifying the key molecular initiating events needed to predict the hazards of chemicals.

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Last Updated (Sunday, 14 February 2010 07:47)

 
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