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2nd Knoxville Workshop on Reactive Toxicity, April, 1-4, 2006

Workshop Information 6.3MB

Workshop Agenda 1.3MB

Workshop Goals

The Knoxville Workshop was convened to evaluate the use of model nucleophiles as an organizing principle for predicting the many adverse effects of reactive chemicals. Briefly, the reactivity of chemicals toward model nucleophiles such as glutathione and lysine are used as independent variables to correlate with skin sensitization, inhalation toxicity, hepatocyte toxicity and fish toxicity. These same reactivity parameters are used as reference data to classify the reactivity mechanisms and predict reactivity directly from chemical structure.

The workshop found that there reaction rates with the thiol moiety of glutathione are appearing in the literature under a variety of experimental conditions. The largest systematic data set is that of the University of Tennessee College of Veterinary Medicine which totals more than 250 chemicals, and efforts are planned to compare the various methods before the 3rd Knoxville Workshop. These abiotic reactions rates were found to be extremely powerful in predicting a variety of effects of the chemicals.

Last Updated (Saturday, 13 February 2010 18:25)