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2nd McKim Workshop on Reducing Data Redundancy in Cancer Assessment May 8-10, 2012, Baltimore

Duluth

The objectives of this workshop series are (1) to review QSAR screening methods for grouping chemicals based on their potential to induce carcinogenesis through genotoxic and epigenetic pathways, and (2) to evaluate the combined use of structural domains and in vitro data to reduce the need for the rodent carcinogen assay. The 1st McKim Workshop focused on genotoxic carcinogens, and on the potential for the cell transformation assay to identify epigenetic carcinogens. This 2nd workshop will further explore key events in epigenetic pathways as well as discuss the structural attributes for chemicals that impact those pathways.

Agenda

Tuesday May 8
09h00 Welcome & Introductions
09h15 Review of 2010 Workshop Discussions: Aligning the domains of in vitro tests and QSAR models for identification of potential carcinogens - Gilman Veith, International QSAR Foundation, Two Harbors MN
09h45 Highlighting the need for AOPs in streamlining hazard assessment methods - Kate Willett, Regulatory Toxicology, Risk Assessment and Alternatives, The Humane Society of the United States, Washington DC
10h00 Overview of regulatory contexts in US EPA for identification of chemicals of concern with respect to carcinogenicity - Vicki Dellarco, Office of Pesticide Programs, US EPA Washington DC
10h30 Break
10h45 Health Canada experiences with early identification of potential carcinogens - Sunil Kulkarni , Hazard Methodology Division, Existing Substances Risk Assessment Bureau Health Canada, Ottawa ON
11h30 In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for genotoxic chemicals - Romualdo Benigni, Experimental and Computational Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy

12h15 Catered Lunch
13h15 An overview of integration of DNA profilers, metabolism and test data in the QSAR Toolbox - Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Prof. AS. Zlatarov University, Bourgas, Bulgaria
14h15 An evaluation of the QSAR Toolbox profilers for identifying DNA reactive and genotoxic chemicals – Terry Schultz, Professor Emeritus University of Tennessee and OECD Secretariat, Paris
15h00 Simulating metabolic activation of proelectrophiles in profiling – Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Prof. AS. Zlatarov spielautomaten University, Bourgas, Bulgaria
15h30 Break
15h45 Summarizing the decision tree for identifying genotoxic chemicals – Gilman Veith, International QSAR Foundation, Two Harbors, MN
16h00 Overview of major mechanisms of nongenotoxic carcinogenesis and exploration of possible (Q)SAR – Yin-tak Woo, Senior Toxicologist, Office of Pollution Prevention and Toxics, USEPA, Washington DC
17h00 Adjourn
Dinner on your own

Wednesday May 9
09h00 Advances for nongenotoxic carcinogens in cell transformation – Paule Vasseur, Laboratoire Interactions, Ecotoxicologie, Biodiversité, Ecosystèmes, University of Metz, France
09h45 In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for epigenetic chemicals – Romualdo Benigni, Experimental and Computational Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy
10h30 Break
10h45 Identifying non-genotoxic carcinogens based on mechanisms - Jan van Benthem, Department of Carcinogenesis, Mutagenesis and Reproductive Toxicology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
11h30 The role of signal transduction pathways in epigenetic carcinogenesis - Elizabeth Wattenberg, School of Public Health, University of Minnesota, Minneapolis MN

12h15 Catered Lunch
13h15 Oxidative stress and Cell transformation - Marie-Aline Maire, Institut National de Recherche et de Sécurité, Vandoeuvre Les Nancy, France
2:00 General Discussion- All
15h30 Break
15h45 Potential role for endocrine disruptor expert systems in investigating endocrine system - epigenome interactions – Patricia Schmieder, Molecular and Cellular Mechanisms Branch, US EPA, Duluth MN
17h00 Adjourn
Dinner on your own

Thursday May 10
09h00 Discussion of the prospects for tiered screening methods to reduce reliance on the rodent carcinogen assay- All
10h30 Coffee
10h45 Workshop summary and implementing next steps
12h00 Catered Lunch

Last Updated (Saturday, 11 August 2012 19:19)

 

Participants

Romualdo Benigni Experimental and Computational Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy

Vicki Dellarco Senior Science Advisor, Office of Pesticide Programs, US EPA Washington, DC

Sunil Kulkarni Hazard Methodology Development Group, Health Canada, Ottawa, ON Canada

Marie-Aline Maire Institut National de Recherche et de Sécurité, Vandoeuvre les Nancy, France

Ovanes Mekenyan Laboratory of Mathematical Chemistry, Prof. AS. Zlatarov University, Bourgas, Bulgaria

Joseph Manuppello Science Advisor, PETA, Norfolk, VA

Patricia Schmieder Molecular and Cellular Mechanisms Branch, US EPA Duluth, MN

Terry Schultz OECD, Paris U of Tennessee Emeritus, Knoxville, TN

Kristie Sullivan Scientific and Policy Advisor, Physicians pokie machines Committee for Responsible Medicine, Washington, DC
Jan van Benthem Department of Carcinogenesis, Mutagenesis and Reproductive Toxicology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands

Paule Vasseur Laboratoire Interactions, Ecotoxicologie, Biodiversité, Ecosystèmes, University of Metz, France

Gilman Veith International QSAR Foundation Two Harbors, MN

Elizabeth Wattenberg School of Public Health University of Minnesota, Minneapolis, MN

Kate Willett Director, Integrative Systems Toxicology,USEPA, RTP-NC

Kristie Sullivan Regulatory Toxicology, Risk Assessment and Alternatives The Humane Society of the United States, Washington, DC

Yin-tak Woo Senior Toxicologist, Office of Pollution Prevention and Toxics, USEPA Washington, DC

Last Updated (Wednesday, 08 August 2012 19:46)

 

Presentations

Tuesday May 8, 2012
Review of 2010 Workshop Discussions: Aligning the domains of in vitro tests and QSAR models for identification of potential carcinogens Gil Veith
Highlighting the need for AOPs in streamlining hazard assessment methods Kate Willett ppt
Overview of regulatory contexts in US EPA for identification of chemicals of concern with respect to carcinogenicity Vicki Dellarco ppt
Health Canada experiences with early identification of potential carcinogens Sunil Kulkarni ppt
In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for genotoxic chemicals Romualdo Benigni pdf
An overview of integration of DNA profilers, metabolism and test data in the QSAR Toolbox Ovanes Mekenyan ppt
An evaluation of the QSAR Toolbox profilers for identifying casino uk DNA reactive and genotoxic chemicals Terry Schultz ppt
Simulating metabolic activation of proelectrophiles in profiling Ovanes Mekenyan ppt
Overview of major mechanisms of nongenotoxic carcinogenesis and exploration of possible (Q)SAR Yin-Tak Woo ppt
Wednesday May 9,2012
Advances for nongenotoxic carcinogens in cell transformation Paule Vasseur pdf
In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for epigenetic chemicals Romualdo Benigni pdf
Identifying non-genotoxic carcinogens based on mechanisms Jan van Benthem ppt
The role of signal transduction pathways in epigenetic carcinogenesis Elizabeth Wattenberg pdf
Oxidative stress and Cell transformation Marie-Aline Maire ppt
Potential role for endocrine disruptor expert systems in investigating endocrine system - epigenome interactions Patricia Schmieder pptx

Last Updated (Saturday, 11 August 2012 19:42)